Second Mitochondrial Activator of Caspase

SMAC is a mitochondrial protein that promotes cytochrome c- and TNF receptor-dependent activation of apoptosis by inhibiting the effect of IAP – a group of ...

由 G Martinez-Ruiz 著作 · 2008 · 被引用 188 次 — Smac/DIABLO sensitizes tumor cells to die by apoptosis. Several studies have shown that overexpression of Smac/DIABLO sensitizes neoplastic ...

由 C Du 著作 · 2000 · 被引用 5087 次 — Smac is normally a mitochondrial protein but is released into the cytosol when cells undergo apoptosis. Mitochondrial import and cleavage of its signal peptide ...

由 SK Pandey 著作 · 2022 · 被引用 3 次 — Mitochondrial SMAC/Diablo induces apoptosis by binding the inhibitor of apoptosis proteins (IAPs), thereby activating caspases and, subsequently, apoptosis.

由 L Flanagan 著作 · 2010 · 被引用 78 次 — During apoptosis, Smac, similar to cyt-c, is released into the cytosol through pores formed by activated Bax or Bak proteins. Bax/Bak pores seem ...

由 S McKenna 著作 · 2021 · 被引用 18 次 — SMAC is one of the proteins released from the mitochondria upon activation of the intrinsic apoptotic pathway and is an inhibitor of IAPs.

由 C Adrain 著作 · 2001 · 被引用 613 次 — Smac/DIABLO is a mitochondrial protein that potentiates some forms of apoptosis, possibly by neutralizing one or more members of the IAP family of apoptosis ...

Smac indirectly promotes apoptosis by blocking the inhibitory action of inhibitor of apoptosis proteins (IAPs) on caspases 3, 7, and 9. The final steps of ...